Researchers present the role of cyclic fasting and fasting-mimicking diets (FMD) in cancer therapy.
By Pooja Toshniwal PahariaReviewed by Danielle Ellis, B.Sc.Aug 8 2024 In a recent review published in Cell Metabolism , researchers present the role of cyclic fasting and fasting-mimicking diets in cancer therapy .
About the review In the present review, researchers discuss existing preclinical and clinical research and biological mechanisms underlying the effects of FND in oncological treatment. The decrease in glucose obtainability caused by fasting/FMD may induce tumor cells to maximize adenosine triphosphate generation by oxidative phosphorylation in mitochondria of glucose or other metabolic compounds such as amino and fatty acids.
FMD lowers blood insulin-like growth factor-1 levels, which inhibits IGF-1R activity in tumor cells and recruits cytotoxic clusters of differentiation 8-expressing T cells into the tumor. It also reduces CD73 levels, which reduce M2 macrophage infiltration and chemokine C-C motif ligand 2 levels in tumors.
Cancer Treatment Fasting Adenosine Blood Cancer Therapy Cell Cell Metabolism Chemotherapy Cholesterol Colorectal Diet DNA Fatty Acids Gemcitabine Glucose Growth Factor Immune System Immunomodulatory Immunotherapy Insulin Intracellular Kinase Leukemia Ligand Metabolism Metabolites Oncogene PD-L1 Phosphorylation Preclinical Protein Rapamycin Receptor Research Tumor
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