Science, Space and Technology News 2024
A dying neuron damaged by tau protein. Tau is involved in Alzheimer’s disease and other dementias. A new model in nonhuman primates is opening the possibility of testing treatments before extensive brain cell death and dementia set in. Credit: Danielle Beckman/UC Davis, focusing on the tau protein implicated in the disease.
The sick neurons then cause an inflammatory response mediated early on by microglial cells. Eventually, neurons die, leaving neurofibrillary tangles of tau protein, one of the key markers of Alzheimer’s and other dementing illnesses. Over six months, they followed the spread of tau protein, affected cells, and inflammation through the animals’ brains using PET and MRI imaging, biomarkers, and by microscopy.
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