Science, Space and Technology News 2024
Studies demonstrate the regeneration of mouse brain circuits with rat stem cells, providing new insights into neurological restoration and cross-species brain development. Credit: SciTechDaily.com
“This research helps to show the brain’s potential flexibility in using synthetic neural circuits to restore brain functions,” says Kristin Baldwin, a professor atin New York and corresponding author of one of the two papers. Baldwin’s team restored mouse olfactory neural circuits, the interconnected neurons in the brain responsible for the sense of smell, and their function using stem cells from rats.
The researchers didn’t test whether the forebrain from rat stem cells changed mice’s behaviors. “There’s a lack of good behavioral tests to distinguish rats from mice,” Wu says. “But from our experiment, it seems like these mice with rat forebrain don’t behave out of the ordinary.”In the other study, Baldwin’s team used specific genes to either kill or silence mouse olfactory sensory neurons used for the sense of smell and injected rat stem cells into the mice embryos.
Blastocyst complementation is still far from clinical application in humans, but both studies suggest stem cells from different species can synchronize their development with the host’s brain.
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