A team of researchers at Rice University, led by Anna-Karin Gustavsson, has created soTILT3D, an imaging platform that enhances super-resolution microscopy. This platform allows for rapid and accurate 3D imaging of multiple cellular structures, while the extracellular environment can be controlled and adjusted. The research was published in Nature Communications.
Rice University Nov 27 2024 A team of researchers led by Anna-Karin Gustavsson at Rice University has developed an innovative imaging platform that promises to improve our understanding of cellular structures at the nanoscale.
The soTILT3D platform directly addresses these challenges. By synergistically integrating an angled light sheet, a nanoprinted microfluidic system and advanced computational tools, soTILT3D significantly improves imaging precision and speed, allowing for clearer visualization of how different cellular structures interact at the nanoscale -; even in conventionally challenging samples.
The platform also incorporates a custom-designed microfluidic system with an embedded customizable metalized micromirror, which enables precise control over the extracellular environment and allows for rapid solution exchange, which is ideal for sequential multitarget imaging without color offsets while also allowing for reflection of the light sheet into the sample.
The platform's PSF engineering enables 3D imaging of single molecules, while deep learning handles dense emitter conditions which conventional algorithms have trouble with, which significantly improves the acquisition speed." Related StoriesSoTILT3D's microfluidic device also supports automated Exchange-PAINT imaging, allowing different targets to be visualized sequentially without the color offsets common in multicolor approaches when imaging in-depth at the nanoscale.
Rice University Anna-Karin Gustavsson Sotilt3d Super-Resolution Microscopy Nanoscale Imaging Extracellular Environment Cellular Structures
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