Study found no reliable clinical biomarkers for diagnosing PASC (long COVID) from routine laboratory tests, despite minor differences in some measures between infected and non-infected individuals.
By Tarun Sai LomteReviewed by Susha Cheriyedath, M.Sc.Aug 13 2024 A recent study published in the journal Annals of Internal Medicine investigated clinical laboratory markers of severe acute respiratory syndrome coronavirus 2 infection and its post-acute sequelae .
The authors developed a PASC index based on 12 symptoms distinguishing previously infected people from non-infected individuals. Moreover, they also identified various PASC clusters or sub-phenotypes. Clinical laboratory tests that distinguish between individuals with and without PASC might help in PASC diagnosis, prevention, prognosis, and treatment. While studies have identified potential PASC-associated biomarkers, they reported inconsistent findings.
About the study In the present study, researchers evaluated clinical laboratory biomarkers of SARS-CoV-2 infection and PASC. People aged ≥ 18, regardless of prior SARS-CoV-2 infection, were recruited in the United States . Subjects completed a physical examination and surveys and provided samples for laboratory tests at enrolment.
Related StoriesIn cluster 3, brain fog, fatigue, and PEM were more frequent, while cluster 4 represented increased frequency of palpitations, gastrointestinal symptoms, brain fog, PEM, dizziness, and fatigue. In the primary analysis, the team assessed whether SARS-CoV-2 infection resulted in persistent abnormalities in laboratory measures between those with and without prior infection.
Brain Brain Fog Coronavirus Diabetes Dysbiosis Fatigue Frequency Hba1c Laboratory Medicine Platelet Respiratory SARS SARS-Cov-2 Severe Acute Respiratory Severe Acute Respiratory Syndrome Syndrome
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