Science, Space and Technology News 2024
Researchers from Flinders University, along with international experts, have discovered that the PF4 antibodies causing VITT after adenovirus vector-based COVID-19 vaccination share identical molecular signatures with those found in similar cases following natural adenovirus infection. This finding, using a new approach developed at Flinders, has significant implications for understanding the genetic risk factors and improving future vaccine development.
VITT was found to be caused by an unusually dangerous blood autoantibody directed against a protein termed platelet factor 4 . In separate research in 2023, researchers from Canada, North America, Germany, and Italy described a virtually identical disorder with the same PF4 antibody that was fatal in some cases after natural adenovirus infection.researchers Dr.
Flinders University immunology researchers Dr. Jing Jing Wang and Professor Tom Gordon. Credit: Flinders FoundationNow, the Flinders group has collaborated with this international group of researchers to find that the PF4 antibodies in both adenoviruses infection-associated VITT and classic adenoviral vectored VITT share identical molecular fingerprints or signatures.
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