Researchers confirmed the presence of replication-competent Oropouche virus in semen, raising concerns about potential sexual transmission following a traveler's infection.
By Vijay Kumar MalesuReviewed by Susha Cheriyedath, M.Sc.Oct 9 2024 New findings reveal the presence of replication-competent Oropouche virus in semen, posing fresh questions about sexual transmission risks and public health safety.
Background Oropouche fever is endemic to the Amazon basin, but outbreaks have spread to countries like Brazil, Peru, Panama, and beyond, with over half a million cases since its discovery. In August 2024, a 42-year-old man from Italy was evaluated for acute febrile illness after returning from Cuba, where he traveled from July 19 to 29. He experienced high fever, headache, and general malaise shortly before his return, with symptoms reemerging four days after onset. Clinical evaluations indicated no meningeal irritation, rash, or lymphadenopathy .
Laboratory investigations showed a leukocyte count within normal reference limits and no signs of thrombocytopenia . Blood cultures returned negative results, and specific RT-PCR assays for dengue, chikungunya, and Zika viruses were also negative. However, Oropouche fever was diagnosed through two OROV-specific RT-PCRs targeting the small genomic segment, confirming the virus's presence in whole blood, serum, and urine samples collected on day four of symptom onset.
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