Medical imaging is no longer in Kansas, Toto, as a team led by Penn State researchers brings traditional black and white diagnostic images of X-rays and traditional CT scans into technicolor.
Penn StateOct 30 2024 The researchers developed novel contrast agents that target two proteins implicated in osteoarthritis, a degenerative joint disease commonly characterized as wear-and-tear arthritis.
And that visualization is especially important when it comes to diseases such as osteoarthritis, which can progress unnoticed until clinical presentation, which is often at an advanced and irreversible stage. Early intervention could reduce symptoms and improve lifestyle, if we have the tools to enable early diagnosis and longitudinal disease tracking. We can enhance imaging techniques to detect early cartilage changes at a molecular level, and that could help improve diagnosis and monitoring.
The researchers designed two K-edge metal nanoprobes, made of praseodymium and hafnium. The probes target two proteins in cartilage tissue: aggrecan and aggrecanase, respectively. Aggrecan, which helps provide structure and the ability to bear weight to cartilage, is abundant in healthy joints and in early stages of osteoarthritis. Aggrecanase, which cleaves aggrecan and limits cartilage's abilities, is abundant in the late stages of osteoarthritis.
However, Pan explained, advanced detector technologies like photon-counting CT scanning and K-edge imaging -; which his lab has worked on for more than a decade -; have enabled highly precise and detailed imaging.
Adipose Arthritis Bone Cartilage Computed Tomography CT CT Scanning Diagnostic Medical Imaging Nanoparticles Osteoarthritis Protein Research Tomography
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