Scientists Discover Ancient Anti-Cancer Mechanism: DISE

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Scientists Discover Ancient Anti-Cancer Mechanism: DISE
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Science, Space and Technology News 2023

A new study reveals an ancient anti-cancer mechanism, DISE, emphasizing the evolutionary role of RNA interference in combating cancer.delves into the depths of the cellular world, unveiling a potential ancient anti-cancer mechanism. The research was led by scientists Monal Patel and Marcus E. Peter fromDespite significant advancements in cancer therapy, cancer still ranks among the leading causes of death worldwide.

“DISE was discovered through our work on CD95 and its ligand, CD95L, where we found that more than 80% of 26 different short interfering RNAs and short hairpin RNAs derived from the two genes, killed multiple cancer cell lines via simultaneous activation of multiple cell death pathways; and we were unable to find a way to inhibit this form of cell death.”

Reference: “DISE, an ancient anti-cancer mechanism that senses mutational load in cancerous cells? ” by Monal Patel and Marcus E. Peter, 25 September 2023,SciTechDaily: Home of the best science and technology news since 1998. Keep up with the latest scitech news via email or social media. Unlocking Light’s Mysteries – Scientists Discover New System To Control the Chaotic Behavior of Light

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