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A new technique that produces 3D models of individual crystals has opened a window for scientists to see the subtle deviations that emerge in their otherwise perfect patterns.
For all its ingenuity, though, X-ray crystallography has its limits, which are summed up rather neatly by the opening sentence of a new paper published inThe paper describes a new technique that promises to finally change that fact – albeit not for crystals composed of repeating units of individual atoms., which are large enough to be seen under a conventional microscope and to manipulate in a manner that would be impossible for atoms.
Many atomic-scale crystals, by contrast, are made up of two or more elements and form complex, three-dimensional structures. The new study demonstrates the effectiveness of seeding these individual colloidal particles with a fluorescent dye to distinguish one species from the other – and, crucially, continues to do so once they have formed crystals. This means that at long last, scientists can"look inside" a fully formed crystal and make direct observations of its innards.
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