Existing drugs could be repurposed following the discovery, according to researchers, who have also developed a new compound using their findings.
A drug breakthrough could usher in a “new era” for how an aggressive form of blood cancer is treated, scientists have said.
In the presence of oxygen, these enzymes – known as hypoxia-inducible factor prolyl hydroxylases – become active to target and destroy proteins called hypoxia-inducible factor .The study, co-led by the Institute of Cancer Research, London, and the University of Oxford, explored if boosting HIF levels could prevent the progression of AML.
The research team has also created a new compound called IOX5, which inhibits PHDs without impacting other enzymes. It is hoped the findings of the research – which was funded by Cancer Research UK, Medical Research Council and Barts Charity, and published in Nature Cancer – will now be tested in clinical trials.
Professor Kristian Helin, chief executive of The Institute of Cancer Research, London, said: “Cancer exists in a complex ecosystem within the body.
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