Science, Space and Technology News 2024
A study led by MRC researchers found genetic variants in the BSN and APBA1 genes significantly impact obesity risk, with these effects notably manifesting in adulthood. Utilizing data from over 500,000 individuals, this research suggests a novel biological mechanism for obesity linked to brain signaling and proposes potential new targets for treatment.
The researchers used UK Biobank and other data to perform whole exome sequencing of body mass index in over 500,000 individuals., also known as Bassoon, can raise the risk of obesity as much as six times and was also associated with an increased risk of non-alcoholic fatty liver disease and of type 2 diabetes.
Previous research has identified several obesity-associated gene variants conferring large effects from childhood, acting through the leptin-melanocortin pathway in the brain, which plays a key role in appetite regulation.encode proteins found in the brain, they are not currently known to be involved in the leptin-melanocortin pathway.
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