Review explores how microRNAs (miRNAs) interact in cancer development, their potential in diagnosis, and innovative therapeutic strategies, including overcoming chemotherapy resistance.
By Dr. Liji Thomas, MDReviewed by Benedette Cuffari, M.Sc.Oct 20 2024 Groundbreaking research uncovers the role of mi RNA s in driving cancer while offering innovative diagnostic tools and therapies, including solutions to chemotherapy resistance.
After their synthesis as primary miRNAs, miRNAs undergo processing to become mature functional miRNAs. Functional miRNAs are found in both intron and exon noncoding RNAs and the introns of pre-RNAs. Interactions between miRNA are currently being explored through high-throughput RNA sequencing , such as PANDORA-seq and Nanopore MinION RNA-Seq. Imaging technologies, including single-molecule imaging and cryo-electron microscopy, can also provide important insights into the dynamic interactions between miRNAs.
Bioinformatics can be coupled with computational techniques to predict how certain miRNAs will function. Combining this computational data with experimental information can improve the prediction accuracy of miRNA interactions while also revealing unknown associations between regulatory and target molecules.
Newer delivery systems like nanotechnology offer novel applications, including diagnostic and therapeutic tools like biosensors and miRNA-nanoparticle drugs. Nanotechnology improves drug bioavailability, specificity, and the effectiveness of miRNAs.
Cancer Diagnosis Animal Model Apoptosis Bioinformatics Caenorhabditis Elegans Cell Cell Cycle Chemotherapy Diagnostic Drugs Efficacy Exon Gene Genes Imaging Immunotherapy Intron Introns Molecule Nanoparticle Nanotechnology Oncology Protein Research RNA Transcription Translation Tumor
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