Scientists from La Jolla Institute for Immunology (LJI) and The University of Southampton, UK, have uncovered a group of immune cells that may drive severe asthma.
Reviewed by Megan Craig, M.Sc.Oct 20 2023 These cells, called cytotoxic CD4+ tissue-resident memory T cells, gather in the lungs and appear to possess the molecular weaponry to cause the most harm in men who developed asthma later in life.
Ramesh Kurukulaaratchy, BM, DM, FRCP, WATCH study director, Associate Professor at the University of Southampton and researcher at the NIHR Southampton Biomedical Research Centreand their role in asthma development-;as they work to bring personalized therapies to asthma patients. The scientists aren't sure why these T cells tend to cause problems for older men. Seumois is interested in solving this mystery through LJI's Center for Sex-Based Differences in the Immune System. "We know that females have a different immune landscape," says Seumois. "So we're interested in investigating this question further."
Spotting this immune cell imbalance was an important clue that this patient group represented a new asthma subtype.
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