The most detailed study to date on the mechanisms by which a common type of bacterium, Staphylococcus aureus, adapts to living on the human body could help improve the prevention, diagnosis, and treatment of certain infections.
Wellcome Trust Sanger InstituteJan 13 2025
This large-scale genetic analysis uncovered several genes and biological pathways that were not previously known to be involved in S. aureus colonisation. However, in those with a weakened immune system, S. aureus can get into the bloodstream and cause infections. These can range from mild skin and soft tissue infections to more severe infections, including sepsis and pneumonia.
Related StoriesThe researchers identified changes in genes associated with nitrogen metabolism, suggesting that this is a key metabolic process necessary for the colonisation of humans by S. aureus. They also identified mutations in genes that could influence the way the bacteria interact with human cells and the immune system.
Overall, this new research reveals key biological processes that S. aureus employs to survive in humans. The study of the evolution and genetic adaptation of bacteria in their natural environment, either during the asymptomatic colonization of their carriers or in the establishment and course of infections, can help improve the prevention, diagnosis, and treatment of disease.
Bacteria Biomedicine Evolution Genetic Genomics Immune System Laboratory Research Skin Staphylococcus Aureus Students
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