Researchers used stem-cell derived organoids from Crohn's disease patients to identify two molecular subtypes, paving the way for personalized treatments targeting specific disease characteristics.
By Pooja Toshniwal PahariaReviewed by Susha Cheriyedath, M.Sc.Oct 2 2024 By developing lab-grown intestines, researchers identified two unique molecular subtypes of Crohn’s disease, providing critical insights for personalized therapeutic approaches to treat the condition more effectively.
Crohn's disease is a long-lasting digestive illness with varying symptoms among different individuals. Inflammation drives pathologic changes in CD, which is multifactorial in origin. There is currently no perfect way to study CD before testing on humans, and there is no cure.
Study outline: Creation of a living biobank of adult stem cell-derived PDOs for enhancing personalized therapeutics in CD Results The organoids mimicked the actual disease conditions in the intestines of CD patients. The team identified two types of CD in the organoids: immune-deficient infectious type and stress and senescence-induced fibrostenotic type . IDICD is characterized by impaired immune activity against bacteria, while S2FCD exhibits signs of oxidative stress and cellular aging, leading to the thickening and narrowing of the intestines.
Cell Cell Proliferation Crohn's Disease Drugs Evolution Inflammation Inflammatory Bowel Disease Laboratory Medicine Microscopy Organoids Preclinical Proliferation Stress Therapeutics
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