Scientists unveil a 3D photoacoustic scanner that speeds up vascular imaging for real-time clinical use

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Scientists unveil a 3D photoacoustic scanner that speeds up vascular imaging for real-time clinical use
VascularAnatomyArthritis
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Researchers have developed a rapid 3D photoacoustic tomography (PAT) scanner for high-resolution vascular imaging, enabling fast and detailed visualization of the microvasculature.

By Tarun Sai LomteReviewed by Susha Cheriyedath, M.Sc.Oct 1 2024 With the ability to capture detailed images of blood vessels in seconds, this breakthrough technology promises to revolutionize diagnostics in fields like rheumatology, oncology, and cardiovascular medicine.In a recent study published in the journal Nature Biomedical Engineering, researchers developed a three-dimensional photoacoustic tomography scanner for rapid vascular imaging.

PAT overcomes range-resolution concerns since ultrasound waves are scattered less than photons in the tissue. Notwithstanding, PAT implementation presents instrumentation-related challenges. Conventional piezoelectric ultrasound detectors are commonly used in PAT scanners but have poor sensitivity for sub-100 µm element sizes and insufficient broadband frequency response.

a, Index fingertip. Left: x-y and x-z depth-to-colour encoded MIPs. Right: expanded view greyscale MIPs showing en-face view of cutaneous vasculature and cross-sectional views of a venous valve . b, Ring fingertip. Left: x-y depth-to-colour encoded MIP. Right: expanded view greyscale MIPs showing cross-sectional view of dermal microvascular anatomy, epidermis , digital artery and pseudoaneurysm . Bottom: expanded view y-z greyscale cross-sectional MIP showing distal branches and DA.

Further, at 1 kHz, the A-line rate increased to 64,000/s, and the total scan time was 0.3s. Image quality was not excessively compromised. To demonstrate clinical utility, exploratory case studies were undertaken on patients with suspected vascular changes related to rheumatoid arthritis, peripheral vascular disease , and skin inflammation.

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Vascular Anatomy Arthritis Blood Blood Vessels Diagnostics Epidermis Foot Frequency Hair Hemoglobin Imaging Techniques Inflammation Medicine Oncology Optical Imaging Rheumatoid Arthritis Rheumatology Skin Technology Tomography Ultrasound

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