Sense of smell may hold clues to Lewy body pathology: new evidence emerges NatureMedicine smell lewbody pathology cognative brain health
By Pooja Toshniwal PahariaJul 20 2023Reviewed by Lily Ramsey, LLM In a recent study published in the Nature Medicine Journal, researchers evaluated the impact of Lewy body positivity on clinical outcomes such as cognition and smell among cognitively and neurologically unimpaired individuals.Study: Cognitive effects of Lewy body pathology in clinically unimpaired individuals. Image Credit: KaterynaKon/Shutterstock.
About the study In the present study, researchers assessed the influence of Lewy body pathologies on cognition and clinical outcomes using a cerebrospinal fluid-based α-syn-seed amplification assay . The study occurred among 1,182 neurologically and cognitively unimpaired individuals who participated in the BioFINDER-1 and 2 studies.
Related StoriesMotor function was assessed using an informant-based cognitive impairment questionnaire and the unified Parkinson's disease rating scale, Part III . Results The study involved 94 participants with LB, tau, and Aβ pathologies. The majority did not have AD or LB pathology. In comparison, 74 had only Lewy body pathology, 147 had only Alzheimer's disease pathology, and 20 had both Alzheimer's disease and Lewy body pathology.
Only Lewy body-positive individuals developed clinical LBD in the ten years. All pathologies were increasingly common with advancing age, and males had a >2.0-fold greater likelihood of demonstrating LB positivity than females.
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