TV celebrity Sharon Osbourne continues to face challenges in regaining weight after stopping the weight-loss injection Ozempic. Experts raise concerns about the potential long-term effects of GLP-1 drugs.
It's one of the greatest dilemmas patients taking revolutionary weight-loss drugs face: Will they ever be able to stop taking the injections?
This means that many patients who take the appetite-suppressing drugs are hesitant to stop using them – opening up the daunting possibility that thousands may remain on the medicines for the rest of their lives.Instead, months after coming off the injection Ozempic, the reality TV star and music manager is reportedly struggling to regain any weight at all.
Yet she has reportedly not regained any weight, leaving friends worried that the drugs have permanently damaged her body. The drugs mimics a hormone found in the pancreas that is released when the stomach is full after eating. 'We've found that roughly 5 per cent of people who come off these injections seem not be able to put weight back on,' says Dr Alex Miras, consultant endocrinologist at Ulster University, who has been involved in several major GLP-1 trials.
GLP-1 drugs were first designed to treat diabetes, as the injections can lower the dangerously high blood sugar levels experienced by millions of patients. Research shows that patients who stop taking semaglutide – the active ingredient in Ozempic and Wegovy – on average regain about two-thirds of their weight.
'One of the biggest factors that can predict how you will fare once coming off these drugs is how quickly you lost the weight to begin with,' says Dr Nerys Astbury, a diet and obesity expert at the University of Oxford. Regardless of the cause, experts agree that those who come off GLP-1 drugs and immediately put weight back on tend to have one thing in common: They do not exercise.
One Danish study found that, on average, patients who stop taking the drug liraglutide – an older and less effective version of Ozempic – put on around 20lb. 'We are getting our clients who are taking drugs such as Wegovy or Mounjaro to focus on strength-training,' says Mr Durney.GLP-1 drugs such as Ozemic were initially designed as a treatment for diabetes
However, Mr Durney argues that patients with less muscle are also more likely to put weight back on after stopping the injections. 'It's all about muscle-mass,' he says. 'There's no point in doing lots of endurance activity such as running, as that doesn't help build muscle.'
Sharon Osbourne Ozempic Weight Loss GLP-1 Drugs Long-Term Effects
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