The INTERLACE phase III trial, funded by Cancer Research UK and UCL Cancer Trials Centre, assessed whether a short course of induction chemotherapy (IC) prior to chemoradiation (CRT) could reduce the rate of relapse and death among patients with locally advanced cervical cancer.
Reviewed by Megan Craig, M.Sc.Oct 22 2023 As part of an analysis of clinical data, the preliminary results will be presented at the European Society for Medical Oncology congress on Sunday 22 October 2023.
Over the course of 10 years, 500 patients took part in INTERLACE at hospitals in the UK, Mexico, India, Italy and Brazil. Those who participated in the study had been diagnosed with cervical cancer, which was large enough to be seen without a microscope but had not yet spread to other parts of the body. The median age of patients in the trial was 46.
Our trial shows that this short course of additional chemotherapy delivered immediately before the standard CRT can reduce the risk of the cancer returning or death by 35%. Professor Jonathan Ledermann, senior author of the results from UCL Cancer Institute, said: "Cervical cancer is a disease that often strikes women in their thirties or younger. Those with locally advanced disease have a relatively high chance of relapse and the disease can take a huge toll on patients and their families. This makes the results of the INTERLACE trial, which significantly improves overall survival, an important advance in treatment.
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