Short night-time sleep linked with nearly doubled risk of clogged leg arteries

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Short night-time sleep linked with nearly doubled risk of clogged leg arteries
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Sleeping less than five hours a night is associated with a 74% raised likelihood of developing peripheral artery disease (PAD) compared with seven to eight hours. That's the finding of a study published today in European Heart Journal—Open.

Sleeping less than five hours a night is associated with a 74% raised likelihood of developing peripheral artery disease compared with seven to eight hours. That's the finding of a study published today in"Our study suggests that sleeping for seven to eight hours a night is a good habit for lowering the risk of PAD," said study author Dr. Shuai Yuan of the Karolinska Institute, Stockholm, Sweden.

The study included more than 650,000 participants and was conducted in two parts. First, the researchers analyzed the associations of sleep duration and daytime napping with the risk of PAD. In the second part, the investigators usedto perform naturally randomized controlled trials—called Mendelian randomization—to examine causality of the associations.

Taken together, the strongest evidence was for short sleep, where the relationship with PAD went both ways. In an observational analysis of 53,416 adults, sleeping less than five hours a night was associated with a nearly doubled risk of PAD compared with seven to eight hours .

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