Simultaneous radiation and immunotherapy found to be beneficial for a subset of lung cancerpatients NatureGenet naturecancer
aneuploidy were found to have significantly better survival if RT was added to ICB. By contrast, there was no survival benefit for patients with low aneuploidy when adding RT to ICB treatment.
"A key observation was that radiation therapy alone caused depletion of important immune cells within the tumor, however, with concurrent therapy there was enrichment of immune cells and improved elimination of tumor cells that led to positive survival outcomes in mNSCLC patients," Pitroda said. Tumors with a high degree of aneuploidy had a worse prognosis because these patients did not respond to immunotherapy alone. In addition, tumor aneuploidy complemented tumor mutational burden —an established biomarker across many cancers for immunotherapy response. Patients with high TMB often respond well to immunotherapy, and patients with low TMB usually do not.
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