Surgical teams at NYU Langone Health performed the world's first genetically modified pig kidney transplants into a human body in September and November 2021, and then transplanted two pig hearts in the summer of 2022.
May 22 2024NYU Langone Health / NYU Grossman School of Medicine Surgical teams at NYU Langone Health performed the world's first genetically modified pig kidney transplant s into a human body in September and November 2021, and then transplanted two pig hearts in the summer of 2022. These procedures were done in patients declared dead based on neurologic criteria and maintained on ventilators with the consent of their families.
The study showed that the transplanted pig kidneys, while not rejected outright by the recipients' bodies , caused a strong reaction in human peripheral blood mononuclear cells . This set of immune cells can attack transplanted organs much like they attack foreign invaders . While immediate rejection was not seen, in part due to treatment with medications that suppressed it, the new study found evidence of subtler reactions that could cause xenotransplants to fail over time.
Jef Boeke, PhD, a co-senior author on both studies, and director of the Institute for System Genetics at NYU Grossman School of Medicine Related StoriesRapid, massive increases in the number of certain cell types were also seen in decedents receiving pig hearts. In one of the decedents but not the other, activated T cell and natural killer cell populations within the PBMC group increased from about one percent 30 hours post-transplant to more than 20 percent of the entire PBMC population by 66 hours after the procedure.
Antibody Blood Cancer Diagnostics Genes Genetic Genetics Heart Kidney Kidney Failure Kidney Transplant Medicine Multiomics Perioperative Research RNA RNA Sequencing Surgery Therapeutics Transplant Xenograft
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