Chemotherapy alters immune cell landscape in pancreatic cancer nyulangone NatureComms
. These findings and ours imply that TIGIT may be a stronger immunotherapy candidate than PD-1 in PDAC. The higherexpression in treatment-naive samples further suggests that blocking TIGIT may be more effective given as first-line monotherapy or administered concurrently with chemotherapy, and that immune blockade as second-line treatment following chemotherapy may lessen its antitumor effects.
Within two hours of tissue acquisition, the specimen was placed in refrigerated RPMI 1640 medium and transported to the Center for Biospecimen Research & Development at NYU, where the sample was provided for tissue processing.Tissue samples were washed in ice-cold phosphate-buffered saline and grossly assessed for adequacy . Next, the tissue was manually minced with a scalpel blade and filtered through a 40 µm mesh filter to remove any excess debris or blood.
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