Neuroblastoma (NB), the most prevalent extracranial solid tumor in children, poses a significant therapeutic challenge due to its metastasis and high heterogeneity.
Frontiers JournalsNov 3 2024 Neuroblastoma , the most prevalent extracranial solid tumor in children, poses a significant therapeutic challenge due to its metastasis and high heterogeneity. A recent study leveraging single-cell RNA sequencing has uncovered vital molecular mechanisms underlying NB's progression and metastasis, shedding light on potential therapeutic targets.
The investigation involved collecting tumor samples from six NB patients, encompassing both primary and metastatic sites. These samples were subjected to scRNA-seq to generate a comprehensive single-cell expression atlas. The analysis revealed 11 distinct clusters, each with unique transcriptional features, highlighting the heterogeneity of NB.
To further probe the interactions between NB cells and their microenvironment, the researchers analyzed scRNA-seq data from non-malignant cells within the tumor ecosystem. They discovered robust interactions, particularly mediated by the TGFβ signaling pathway, between the 'starter' cells and various immune and stromal cells. This finding points to a complex crosstalk that may influence tumor progression and immune evasion.
Metastasis Neuroblastoma RNA Tumor Cancer Children Gene Malignant Research RNA Sequencing
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