Results from the malaria vaccine trial indicate that GA2 immunization provides significant protection, paving the way for more effective vaccination strategies.
By Vijay Kumar MalesuReviewed by Danielle Ellis, B.Sc.Jan 8 2025 Robust immune response observed in malaria vaccine trial, demonstrating liver-stage attenuation and multipronged immunity
Immunization strategies using whole Plasmodium falciparum sporozoites, particularly those with genetically attenuated late liver stage-arresting parasites , show great promise in achieving high-level protection. Ten participants were immunized with GA2 parasites via 45-55 mosquito bites, while five received placebo mock-immunizations with uninfected mosquitoes. Six weeks later, all participants underwent CHMI using five wild-type Pf3D7-infected mosquitoes.
Study results In the present study, participants aged 15-30 years were recruited between February and March 2023, screened, and randomized. On April 12, 2023, participants were exposed to 50 GA2-infected or uninfected Anopheles stephensi mosquitoes. Six weeks later, all participants underwent a CHMI via bites from five wild-type Pf3D7-infected mosquitoes. Study visits included extensive monitoring for adverse events, safety assessments, and parasite detection using PfqPCR.
Secondary outcomes highlighted precise immune responses in GA2-MB participants. Antibody levels targeting Pf circumsporozoite protein were significantly higher compared to placebo, while antibodies against other antigens, such as Pf apical membrane antigen-1 and merozoite surface protein-1 showed no significant differences.
Vaccine Antibody CD4 Children Efficacy Immune Response Immunity Immunization Liver Medicine Mortality Mosquito Placebo Plasmodium Falciparum Protein Research
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