The Indian-born British author was being introduced to the audience ahead of giving a lecture in New York state, when a man stormed the stage.
Witness Pilar Pintagro told Sky News:"We were very scared because the first place was in the neck and that's where the blood started to splash everywhere, and then he stabbed him in the shoulders and continued stabbing several times because it was so fast.
Another witness Julia Mineeva Braun told Sky News that as Sir Salman was being introduced"all of a sudden from the left-hand side of the stage a short man, all in black, ran out, and he approached Mr Rushdie". Some of the scenes in the 1988 book depict a character modelled on the Prophet Muhammad and this was met with anger from some members of the Muslim community in the UK.
Despite the threat to his life, he continued to write and in 1998 the Iranian government said it would no longer enforce the fatwa. But Ayatollah Khomeini's successor as Supreme Leader, Ayatollah Ali Khamenei, said in 2005 that the fatwa was still valid.
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1029 genomes of self-declared healthy individuals from India reveal prevalent and clinically relevant cardiac ion channelopathy variants - Human GenomicsBackground The prevalence and genetic spectrum of cardiac channelopathies exhibit population-specific differences. We aimed to understand the spectrum of cardiac channelopathy-associated variations in India, which is characterised by a genetically diverse population and is largely understudied in the context of these disorders. Results We utilised the IndiGenomes dataset comprising 1029 whole genomes from self-declared healthy individuals as a template to filter variants in 36 genes known to cause cardiac channelopathies. Our analysis revealed 186,782 variants, of which we filtered 470 variants that were identified as possibly pathogenic (440 nonsynonymous, 30 high-confidence predicted loss of function ). About 26% (124 out of 470) of these variants were unique to the Indian population as they were not reported in the global population datasets and published literature. Classification of 470 variants by ACMG/AMP guidelines unveiled 13 pathogenic/likely pathogenic (P/LP) variants mapping to 19 out of the 1029 individuals. Further query of 53 probands in an independent cohort of cardiac channelopathy, using exome sequencing, revealed the presence of 3 out of the 13 P/LP variants. The identification of p.G179Sfs*62, p.R823W and c.420 + 2 T | C variants in KCNQ1, KCNH2 and CASQ2 genes, respectively, validate the significance of the P/LP variants in the context of clinical applicability as well as for large-scale population analysis. Conclusion A compendium of ACMG/AMP classified cardiac channelopathy variants in 1029 self-declared healthy Indian population was created. A conservative genotypic prevalence was estimated to be 0.9–1.8% which poses a huge public health burden for a country with large population size like India. In the majority of cases, these disorders are manageable and the risk of sudden cardiac death can be alleviated by appropriate lifestyle modifications as well as treatment regimens/clinical interventions. Clinical utility of the obtained variants was
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Salman Rushdie 'on a ventilator and may lose an eye' after being stabbed while on stage at New York eventSir Salman Rushdie is 'on a ventilator and may lose an eye' after being stabbed in the neck and abdomen ahead of an event in upstate New York.
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