Uncapped Leinster prop Jack Boyle is included in Ireland's Six Nations squad, replacing the suspended Tom O'Toole.
Leinster prop Boyle, 22, has been promoted to the squad by interim head coach Simon Easterby having been a development player in Ireland's Autumn Nations Series squad in November.
Lowe has not played since November while Sheehan has been out with an anterior cruciate ligament injury since last summer. Easterby has opted against radical changes for his first squad. Leinster back row Caelan Doris continue as captain, having taken over from Peter O'Mahony for the autumn Tests, while experienced prop Tadhg Furlong returns after missing the November games because of injury.
With Munster scrum-half Craig Casey having been ruled out with a serious knee injury, Connacht's Caolin Blade is included alongside Jamison Gibson-Park and Conor Murray with Ulster's Nathan Doak missing out.
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