Skin pigmentation may act as a 'sponge' for some medications, potentially influencing the speed with which active drugs reach their intended targets, a pair of scientists report in a perspective article published in the journal Human Genomics.
University of California - RiversideOct 10 2024 Skin pigmentation may act as a "sponge" for some medications, potentially influencing the speed with which active drugs reach their intended targets, a pair of scientists report in a perspective article published in the journal Human Genomics .
According to Groen and coauthor Sophie Zaaijer, a consultant and researcher affiliated with UC Riverside who specializes in diversity, equity, and inclusion in preclinical R&D and clinical trials, current FDA guidelines for toxicity testing fail to adequately address the impact of skin pigmentation on drug interactions.
Groen and Zaaijer propose utilizing a new workflow involving human 3D skin models with varying pigmentation levels that could offer pharmaceutical companies an efficient method to assess drug binding properties across different skin types. "It's a monumental task, requiring clear lines of communication between academics, industry researchers, clinicians, and regulators," Zaaijer said. "The future of medicine relies on our capacity to connect these currently isolated operational teams."
The researchers hope to activate the pharmaceutical industry and academia to start doing systematic experimental evaluations in preclinical research in relation to skin pigmentation and drug kinetics.
Cell Drugs Efficacy Genetic Genome Genomics Melanin Nicotine Preclinical Research Skin Pigmentation Smoking
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