The connection between exercise and inflammation has captivated the imagination of researchers ever since an early 20th-century study showed a spike of white cells in the blood of Boston marathon runners following the race.
Now, a new Harvard Medical School study published Nov. 3 in Science Immunology may offer a molecular explanation behind this century-old observation.
Diane Mathis, study senior investigator, Morton Grove-Rasmussen Professor of Immunology in the Blavatnik Institute at HMS "We've known for a long time that physical exertion causes inflammation, but we don't fully understand the immune processes involved," said study first author Kent Langston, a postdoctoral researcher in the Mathis lab. "Our study shows, at very high resolution, what T cells do at the site where exercise occurs, in the muscle."
Related StoriesThe muscle cells of the mice that ran on treadmills, whether once or regularly, showed classic signs of inflammation -; greater activity in genes that regulate various metabolic processes and higher levels of chemicals that promote inflammation, including interferon. More importantly, animals lacking Tregs did not adapt to increasing demands of exercise over time the way mice with intact Tregs did. They did not derive the same whole-body benefits from exercise and had diminished aerobic fitness.
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