On November 27, the prestigious journal Nature will publish the results of an innovative breast cancer research project from the Netherlands.
Netherlands Cancer InstituteNov 27 2024 This study, the SONIA trial, showed that delaying and shortening the duration of a specific anti- cancer therapy in patients with hormone receptor-positive advanced breast cancer leads to similar survival outcomes, while reducing toxicity and achieving substantial cost reductions: over 45 million euros per year in the Netherlands and over 5 billion dollars in the United States.
The SONIA team found that the time in which the breast cancer remained under control was similar in both groups, as was the survival and quality of life. Patients who received a CDK4/6 inhibitor directly, used the drug for approximately 16.5 months longer than patients who received a CDK4/6 inhibitor as second-line treatment. This significantly longer duration of CDK4/6 inhibitor treatment provided no benefit to the patients, but did result in 74% more side effects and more hospital visits.
In addition, the longer duration of CDK4/6 inhibitor treatment associated with first-line use results in significantly higher costs to society . The conduct and results of the SONIA study have led oncologists in the Netherlands to prescribe CDK4/6 inhibitor treatment after failure of first-line endocrine therapy. Anually, 1.700 patients in the Netherlands are eligible for CDK4/6 treatment.
Cancer Cancer Therapy Endocrine Health Insurance Hormone Hospital Receptor Research Research Project
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