Stanford's muscle chips reveal microgravity's impact on muscle regeneration

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Stanford's muscle chips reveal microgravity's impact on muscle regeneration
MuscleAgingCell
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A gentle rumble ran under Ngan Huang's feet as a rocket carrying her research-;live, human muscle cells grown on scaffolds fixed on tiny chips-;lifted off, climbed, and disappeared into the sky to the International Space Station National Laboratory.

Cell PressJul 25 2024 A gentle rumble ran under Ngan Huang's feet as a rocket carrying her research-;live, human muscle cells grown on scaffolds fixed on tiny chips-;lifted off, climbed, and disappeared into the sky to the International Space Station National Laboratory . These chips would help Huang better understand muscle impairment, often seen in astronauts and older adults, and test drugs to counter the condition.

Space is a really unique environment that accelerates qualities associated with aging and also impairs many healthy processes. Astronauts come back with muscle atrophy, or a reduction of muscle function, because the muscle isn't being actively used in the absence of gravity. As space travel becomes more common and available to civilians, it's important to understand what happens to our muscle in microgravity.

Space-traveled muscles also have gene activities that somewhat resemble muscles with sarcopenia, which most commonly affects people ages 60 and older. In a proof-of-concept experiment to test the muscle chip for drug screening, the astronauts spiked the chips with drugs to treat sarcopenia or enhance muscle regeneration. The treatment partially mitigated some of the negative effects of microgravity on the muscles, preventing a metabolic shift to fat formation. Looking into gene activity patterns, the drug-treated muscle in microgravity is more similar to samples from Earth than untreated samples in microgravity.

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