Our bodies divest themselves of 60 billion cells every day through a natural process of cell culling and turnover called apoptosis.
Stanford Medicine Nov 27 2024
The idea came to Gerald Crabtree, MD, a professor of development biology, during a pandemic stroll through the forests of Kings Mountain, west of Palo Alto, California. As he walked, Crabtree, a longtime cancer biologist, was thinking about major milestones in biology. Traditional treatments for cancer -; namely chemotherapy and radiation -; often kill large numbers of healthy cells alongside the cancerous ones. To harness cells' natural and highly specific self-destruction abilities, the team developed a kind of molecular glue that sticks together two proteins that normally would have nothing to do with one another.One of these proteins, BCL6, when mutated, drives the blood cancer known as diffuse large cell B-cell lymphoma.
This approach -; switching something on that is off in cancer cells -; stands in contrast to many other kinds of targeted cancer therapies that inhibit specific drivers of cancer, switching off something that is normally on. Because the technique relies on the cells' natural supply of BCL6 and CDK9 proteins, it seems to be very specific for the lymphoma cells -; the BCL6 protein is found only in this kind of lymphoma cell and in one specific kind of B cell. The researchers tested the molecule in 859 different kinds of cancer cells in the lab; the chimeric compound killed only diffuse large cell B-cell lymphoma cells.
Apoptosis Blood Cell Cell Death Compound Genes Lymphoma Medicine Molecule OCT Oncogene Pandemic Protein Research Tumor
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