The effects of statins via inhibition of interleukin 33 (IL-33).
By Pooja Toshniwal PahariaJun 3 2024Reviewed by Lily Ramsey, LLM In a recent study published in Nature Communications, researchers investigated the effects of statins via inhibition of interleukin 33 .
Inhibiting effector molecules to prevent cancers is difficult, given their involvement in cancer promotion. The researchers examined the impact of interleukin-33 on chronic inflammation in mice. They subjected wild-type mice to chronic inflammatory models, such as dermatitis and pancreatitis. Further, the researchers investigated whether interleukin-33 expression occurred downstream of TANK-binding kinase 1 and interferon regulatory factor 3 signaling by treating epithelial cells with polyinosinic-polycytidylic acid ) and lipopolysaccharides .
To investigate the effects of caerulein injections on mice, researchers used a chronic pancreatitis-associated pancreatic cancer model. They examined IL-33 and IRF3 expression among epithelial cells from 15 identical samples of normal pancreas, pancreatitis, and pancreatic ductal adenocarcinoma. TLR3/4 signaling is a crucial regulator of interleukin-33 levels during chronic inflammation. Statin inhibited interleukin-33 expression by modulating TBK1 signaling in cancer-prone chronic inflammation.
Inflammation Interleukin Adenocarcinoma Anti-Inflammatory Cancer Carcinogenesis Cell Cytokine Dermatitis Dexamethasone Growth Factor Hepatitis Inflammatory Bowel Disease Interferon Membrane Pancreas Pancreatic Cancer Pancreatitis Phosphorylation Pitavastatin Protein Receptor Skin Statin Tumor
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