New research shows how stem cell-derived therapy, targeting treatment-resistant liver cancer through genetically modified NK cells, offers promising new avenues for immunotherapy.
New findings can be applied to NK cells -- an under-appreciated part of the immune system -- as well as CAR T cells, improving both therapies for multiple solid tumor types
"To some extent all tumor cells -- perhaps hepatocellular carcinoma more so -- inhibit immune cells that try to kill them," said UC San Diego School of Medicine Professor Dan Kaufman, M.D., Ph.D., lead author on the study, director of the Sanford Advanced Therapy Center at the university's Sanford Stem Cell Institute and Moores Cancer Center member.
They found that typical NK cells without the disabled receptor, like CAR T cells, were not very effective in battling the cancer."These are pretty resistant tumors -- when we put them in mice, they grow and kill the mice," he said. The five-year survival rate for HCC in humans is less than 20 percent.
Kaufman anticipates that his team's discovery will manifest itself in the clinical trials of many research groups and companies -- whether they're working on CAR T-cell or NK-cell therapies, battling hepatocellular carcinoma or other challenging types of solid tumors. This work was made possible by the NIH/NCI grants U01CA217885, P30CA023100 , and the Sanford Stem Cell Institute at the University of California San Diego.Disruption of TGF-β signaling pathway is required to mediate effective killing of hepatocellular carcinoma by human iPSC-derived NK cellsIn a promising form of immunotherapy known as CAR T-cell therapy, the patient's T cells are engineered to better recognize and attack antigens on the surface of cancer ...
Cancer Brain Tumor Lung Cancer Lymphoma Skin Cancer Prostate Cancer Immune System
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Biden’s new measures to stem illegal border crossings draw legal challengeAdvocacy groups for immigrants sued to overturn President Biden’s latest asylum restrictions on the U.S. southern border
Read more »
Dallas Mavs, NBA unveil new stem lab for Boys and Girls Clubs of Greater DallasTaking time out from the finals, the NBA and the Mavs moved the focus away from the court to young kids and giving back.
Read more »
STEM advocate Marizza Delgado, 25, crowned Miss New York USA 2024Marizza Delgado crowned Miss New York USA 2024
Read more »
New STEM school in Mississippi to boost economic growth and equityThe SR1 College Preparatory and STEM Academy is a public charter school combatting inequity in STEM education.
Read more »
Terrifying new robot has a brain made from human stem cellsScientists in China have created a new robot that uses human stem cells in its brain and its actually kind of terrifying.
Read more »
The Reimagined Chateau Opens at NemacolinNew accommodations, a new nightspot, and new amenities enhance the luxe factor.
Read more »