The new platform's ethically grounded approach promises to reveal much about how human embryos form during the earliest stages of pregnancy.
The new platform's ethically grounded approach promises to reveal much about how human embryos form during the earliest stages of pregnancy.
The question was whether blastoids could gastrulate in vitro. Unlike a blastocyst in vivo, which rolls around in the uterus until it attaches to maternal tissue, blastoids were good at modeling the ball of cells from which life emerges, but it remained unclear whether this in vitro model could model later stages of human development. That is, until Brivanlou developed a platform to allow blastoids to attach in vitro, and thereby progress toward gastrulation.
The primitive streak is a structure that marks the beginning of gastrulation and lays the foundation for the three primary layers of the embryo. One of those layers, the mesoderm, forms during gastrulation and gives rise to muscles, bones, and the circulatory system. The team discovered that, as early as seven days after attachment, they were already able to use molecular markers to detect the earliest signature of a nascent primitive streak and mesodermal cells.
"Many couples can't have babies because the embryo doesn't attach properly, and many miscarriages occur in the first few weeks of pregnancy," De Santis explains."We now have a model system that can help us understand the molecular mechanism that defines whether a pregnancy will be successful or not.
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Stem cell model offers first glimpse of early human developmentIt's one of life's most defining moments—that crucial step in embryonic development, when an indistinct ball of cells rearranges itself into the orderly three-layered structure that sets the stage for all to come. Known as gastrulation, this crucial process unfolds in the third week of human development.
Read more »
Irvine police offer tips to stem wave of residential burglariesIrvine police were offering tips to the public to stem a recent tide of residential burglaries impacting homeowners.
Read more »
University of Rochester holds skill-building workshop for women interested in STEM fieldsNewark, N.Y. — Two back-to-back events took place Friday afternoon for the Greater Rochester Habitat for Humanity.
Read more »
4 Mound STEM School students taken to hospital after ingesting unknown substanceDigital Content Producer at News 5 Cleveland
Read more »
Interior green wall plants treated with antigibberellin plant growth regulators show controlled stem growthAs more businesses recognize the many benefits of having plants in the workplace, interior green walls, also known as living walls, have gained popularity in recent years for their aesthetic appeal and environmental benefits.
Read more »
New Brockton Elementary GEMS and others showcase various STEM projectsThe girls used jalapeno pepper plants and used materials from their classroom. They also coded devices and micro bits to self-water depending on the soil moisture.
Read more »