A team of researchers at Baylor College of Medicine, Texas Children's Hospital, the Hospital for Sick Children in Toronto and collaborating institutions has identified and located a population of stem-like cells that initiates and maintains Group 3 medulloblastoma (Gr3-MB) in the developing brain.
Baylor College of Medicine Jul 9 2024 A team of researchers at Baylor College of Medicine , Texas Children's Hospital , the Hospital for Sick Children in Toronto and collaborating institutions has identified and located a population of stem-like cells that initiates and maintains Group 3 medulloblastoma in the developing brain. Gr3-MB is one of the most aggressive forms of brain cancer in children and is associated with metastatic spread and poor survival.
"We believe that as Gr3-MB develops, it retains characteristics present in embryonic development, resulting in rapid tumor growth," said corresponding author Dr. Michael D. Taylor, professor of pediatrics, hematology – oncology and neurosurgery at Baylor and Texas Children's. He also is the Cyvia and Melvyn Wolff Chair of Pediatric Neuro-Oncology at Texas Children's Cancer and Hematology Center.
We found trace of a lineage of embryonic stem-like cells in Gr3-MB tumors. These cells express a protein called protogenin that is present only in these high risk Gr3-MB but absent in normal postnatal cerebellum." The researchers located the cancer stem-like cells in a specific brain region in the developing cerebellum called the rhombic lip. The cells are embedded in a structure unique to humans that is known as the interposed vascular plexus.
A novel idea to treat Gr3-MB The finding that the tumors have a small population of protogenin-expressing stem-like cancer cells that sustains their growth inspired the researchers to test a novel approach to treating GR3-MBs.
Brain Brain Cancer Cancer CAR T-Cell Cell Children Hematology Hospital Medicine Oncology Preclinical Research T-Cell Tumor Vascular
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Targeting stem-like cells shrinks medulloblastoma tumors in preclinical studyA team of researchers at Baylor College of Medicine, Texas Children's Hospital, the Hospital for Sick Children in Toronto and collaborating institutions has identified and located a population of stem-like cells that initiates and maintains Group 3 medulloblastoma (Gr3-MB) in the developing brain.
Read more »
National poll highlights bedtime battles and sleep struggles among young childrenMany bedtime battles stem from children's after dark worries, suggests a new national poll.
Read more »
Bedtime battles: 1 in 4 parents say their child can't go to sleep because they're worried or anxiousMany bedtime battles stem from children's after dark worries, suggests a new national poll.
Read more »
Neuroscience research leverages stem cells to understand how neurons connect and communicate in the brainNewly published research from Colorado State University answers fundamental questions about cellular connectivity in the brain that could be useful in the development of treatments for neurological diseases like autism, epilepsy or schizophrenia.
Read more »
Boy airlifted to Royal Manchester Children's Hospital and BMW driver arrested after crash in AccringtonA 15-year-old boy was airlifted to hospital after he was knocked off his bike by a suspected drink driver.
Read more »
John McGinn has children at Glasgow hospital in stitches during Scotland team visitThe hospital has shared hilarious footage of 'super' John McGinn touring the wards and entertaining little ones as the national football team recently paid a visit.
Read more »