A protein called STING, previously shown to control a pathway that contributes to antiviral signaling, also plays an important role in cellular stress clearance and cell survival, according to a new paper published in Molecular Cell.
University of PittsburghSep 20 2024
"Our findings suggest that balance of STING's two functions is important for the health of cells and could have implications for future development of therapeutics for age-related diseases," added first author Dr. Bo Lv, Ph.D., a postdoctoral researcher in Tan's lab. While short bursts of STING-mediated inflammation are crucial, in some people this pathway is chronically "on," a state that has been linked with neurodegeneration and other diseases of aging, as well as normal aging.
Both lysosomes and autophagy are tightly linked with longevity and healthspan, the length of time that a person is healthy, suggesting that this protective function of STING is important for healthy aging. The newly discovered function of STING may be an ancient way that cells maintain quality control, clear abnormal materials and manage cellular stress.
Autophagy Cell Cell Biology DNA Exercise Inflammation Lysosomes Ph Protein Stress Therapeutics Transcription
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