Addressing the pressing demand for rapid and inexpensive coagulation testing in cardiovascular care, the team led by Lining Arnold Ju from The University of Sydney, introduces a novel application of repurposed COVID-19 rapid antigen tests (RATs) as paper-based lateral flow assays (LFAs) combined with machine learning for coagulation status...
Strategic reuse of rapid antigen tests for coagulation status assessment using a machine learning approachRepurposed COVID-19 RATs provide an ideal platform for observing differences in blood coagulability. Random Forest image classification algorithms can facilitate rapid coagulation status assessment on a paper-based LFA platform. Credit: authors
This study not only demonstrates the potential of leveraging surplus RATs for coagulation management but also exemplifies a cost-effective, rapid, and smart strategy to enhance clinical decision-making in the post-pandemic era. The innovative repurposing of widely available COVID-19 RATs for coagulability testing is a strategic and intelligent adaptation to the post-pandemic era's abundance of resources and established infrastructure.
Since its adaptation in the late 1960s, ACT is widely employed as a"gold standard," requiring between 2–3 mL of blood, it is utilized during cardiac surgeries, yet it demonstrates significant output variability depending on patient hematocrit levels, with devices like Hemochron showing positive biases of about 56 s during heparinization.
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