Researchers at the Yale School of Medicine found structural and functional alterations in specific brain regions of individuals with opioid use disorder.
Radiological Society of North AmericaDec 10 2024 The study's results were published today in Radiology , a journal of the Radiological Society of North America .
We are in the midst of an opioid epidemic, with millions affected worldwide and more than 80,000 deaths related to opioid overdoses in the U.S. last year alone. We need to get a better understanding of the system-level neural alterations associated with opioid use disorder." Resting state fMRI allows researchers to measure brain activity by detecting changes in blood flow. With resting state fMRI, the connectivity between neural regions-;known as resting state networks-;can be observed while the brain is at rest.
Related StoriesWhole-brain analysis revealed structural and functional alterations in opioid receptor-dense regions in the opioid use disorder group compared to healthy controls. In individuals with opioid use disorder, the thalamus and right medial temporal lobe of the brain were smaller in volume, while the cerebellum and brainstem were larger in volume than in controls.
"We found that alteration patterns in the medial prefrontal cortex-;a core region involved in many mental health conditions-;were different between men and women in the group with opioid use disorder," Dr. Mehta said. "This highlights the importance of assessing sex differences in opioid use disorder neuroimaging studies."
Medicine Cortex Drugs Opioids Ph Radiology Research Thalamus
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