A study confirms the cardiovascular safety of different COVID-19 vaccine doses, showing reduced risks of common cardiovascular events among vaccinated adults in England.
By Dr. Priyom Bose, Ph.D.Reviewed by Benedette Cuffari, M.Sc.Aug 4 2024 A recent Nature Communications study assesses the impact of different coronavirus disease 2019 vaccine doses on cardiovascular safety in millions of adults in England.
Unprecedented and coordinated efforts between governments and the scientific community led to the development of several vaccines, estimated to have prevented about 14.4 million deaths worldwide in the first year of the pandemic. By autumn 2023, about 90% of the population in England 12 years of age and older received at least one COVID-19 vaccine dose.
About the study The current study's researchers utilized whole population longitudinal electronic health records from 45.7 million adults in England between December 8, 2020, and January 23, 2022. The goal was to quantitatively evaluate the associations between first, second, and booster mRNA and non-mRNA COVID-19 vaccine doses and subsequent cardiovascular and thrombotic events.
Study findings In approximately 21 million person-years, 75,655 arterial and 21,230 venous incident thrombotic events were observed. Arterial thrombotic events included ischemic stroke and myocardial infarction, whereas venous events included intracranial venous thrombosis, pulmonary embolism, lower limb deep venous thrombosis, and portal vein thrombosis.
For all vaccine brands and doses, the aHR profiles for pulmonary embolism and deep venous thrombosis were similar to composite venous thrombosis. However, after the first dose of ChAdOx1, the incidence rate of intracranial venous thrombosis was higher. The risk of intracranial venous thrombosis was not raised after the second dose or for any other vaccine brand.
Adenovirus Coronavirus Embolism Ischemic Stroke Myocardial Infarction Myocarditis Pandemic Pulmonary Embolism Research Respiratory SARS SARS-Cov-2 Severe Acute Respiratory Severe Acute Respiratory Syndrome Stroke Syndrome Thrombocytopenia Thrombosis Vaccine
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