Unprecedented genome analysis reveals genetic links between brain structure and disorders like Parkinson's and ADHD, paving the way for innovative treatments.
By Vijay Kumar MalesuReviewed by Lily Ramsey, LLMOct 23 2024 Unprecedented genome analysis ties brain structure variations to genetic risks for Parkinson’s disease and ADHD, offering new treatment possibilities.
Background Subcortical brain structures are crucial in psychiatric, neurological, and developmental disorders, affecting key functions like learning, memory, and motor control. ICV is also associated with neuropsychiatric traits. In total, GWAS data from 74,898 participants of European ancestry were analyzed to investigate the genetic architecture of nine subcortical brain structures, including the nucleus accumbens, brainstem, amygdala, and others.
Study results The GWAS identified 529 significant loci linked to ICV or subcortical brain volumes, with 254 of these loci being independent and unique across brain structures. The brainstem exhibited the highest number of genetic associations, while the amygdala had the fewest. Additionally, subsamples from the UK Biobank showed replicability in the GWAS results for intracranial and subcortical brain volumes, with correlations between the effect sizes of the two subsamples ranging from 0.67 to 0.84.
Genetic Aging Amygdala Blood Gene Genes Genetics Genome Genomic Neuroimaging Research UK Biobank
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Deep brain stimulation shows immediate improvement in arm and hand function post-brain injury, study findsDeep brain stimulation may provide immediate improvement in arm and hand strength and function weakened by traumatic brain injury or stroke, University of Pittsburgh School of Medicine researchers report today in Nature Communications.
Read more »
Why an ADHD diagnosis can be a mixed blessingFor adults, an ADHD diagnosis can be life-saving. But it can also carry risks.
Read more »
Here’s How To Spot The Signs Of ADHD In ChildrenWith so many parents clearly keen to know more about the condition, we spoke to Dr Selina Warlow is a clinical psychologist and founder of The Nook Neurodevelopmental Clinic. Read more on Grazia.
Read more »
Boxing: Tysie Gallagher on ADHD, inspiring her daughter and how she left behind a football careerTysie Gallagher on leaving football for boxing and inspiring her daughter by returning to the ring.
Read more »
Digital games show promise for improving ADHD and depression in youth, but anxiety remains a challengeA meta-analysis reveals gamified digital mental health interventions effectively reduce depression and ADHD in youth, highlighting engagement in treatment.
Read more »
Autistic people and those with ADHD are more likely to have eating disordersMore than 1.1 million Australians are estimated to be living with an eating disorder. Around one-third of these people are neurodivergent.
Read more »