Study examines the incidence of severe COVID-19 in fully vaccinated and boosted high-risk populations SFVAMC JAMA_current COVID19 Coronavirus SARSCoV2 Vaccination Booster
By Dr. Chinta SidharthanSep 29 2022Reviewed by Aimee Molineux In a recent study published in the Journal of the American Medical Association, a team of researchers studied a cohort of patients at the United States Veterans Health Administration facilities to determine the incidence of severe coronavirus disease 2019 outcomes among individuals with primary and booster doses of any combination of BNT162b2, mRNA-1273, and Ad26.COV2.S vaccines.
About the study The present study used a cohort of participants from the U.S. Veterans Health Administration facilities who had received combinations of BNT162b2, mRNA-1273, and Ad26.COV2.S vaccines for their primary and booster vaccinations. The study was conducted between July 1, 2021, and May 30, 2022, and consisted of 1,610,719 participants.
A large number of covariates were considered in the analyses, including demographic factors such as age, sex, race, geographic location, and marital status, as well as parameters such as body mass index and a variety of comorbidities. A comprehensive list of comorbidities spanning cardiovascular, renal, respiratory, vertebral, and immune system-related conditions and cancer were included in the study. Behavioral risks such as smoking and alcohol use were also considered.
The authors believe that their assessment of COVID-9 severity based specifically on pneumonia as an outcome strengthened the study by eliminating potential misclassifications of symptoms or severity.
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