Aspirin can reduce colorectal cancer risk, but its effectiveness varies based on lifestyle factors such as diet, BMI, and smoking. Personalized recommendations are crucial to identify those who would benefit most from aspirin use.
By Vijay Kumar MalesuReviewed by Benedette Cuffari, M.Sc.Aug 7 2024 In a recent study published in the JAMA Oncology , researchers evaluate the association between aspirin use, lifestyle factors, and the risk of colorectal cancer .
Several studies have shown that the anti-cancer effects of aspirin use can vary based on an individual’s diet, body mass index , and smoking habits. Thus, there remains a need for additional research to refine preventive strategies and understand the impact of aspirin on CRC risk across different lifestyle factors.
Data on regular aspirin use were collected every two years starting in 1980 for NHS and 1986 for HPFS. Regular aspirin use was defined as two or more standard 325 mg dose tablets or six or more low-dose tablets of 81 mg every week. Absolute risk reduction and the number needed to treat were calculated. The analyses also considered a potential latency effect of aspirin by evaluating 20-year cumulative CRC incidence.
The 10-year multivariable-adjusted cumulative incidence of CRC was 2.95% among nonregular aspirin users compared to 1.98% among regular users, thus indicating an ARR of 0.97% and NNT of 103. For individual components of the healthy lifestyle score, a greater 10-year ARR was observed among participants with BMI values of 25 or more, moderate/heavy smokers, moderate/heavy alcohol users, and those who reported less physical activity and lower adherence to dietary recommendations.
Cancer Colon Colon Cancer Alcohol Body Mass Index Cell Chronic Colorectal Colorectal Cancer Diet Healthy Lifestyle Neoplasia Oncology Physical Activity Research Smoking
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