Study finds cannabis vaping more harmful than nicotine vaping Cannabis Nicotine Vaping ThoraxBMJ RoswellPark
Study: Not all vaping is the same: differential pulmonary effects of vaping cannabidiol versus nicotine. Image Credit: Amani A / Shutterstock
Studies investigating the health impacts of vaping nicotine have indicated that nicotine aerosols can disrupt the functioning of immune cells, suppress innate immune responses in nasal epithelial cells, and induce chronic respiratory disorders. However, not enough studies are available to determine the health effects of vaping cannabinoids.
For in vivo experiments, both male and female mice were exposed to one puff of nicotine or cannabidiol aerosols for five days a week. The exposure was continued for two weeks. For in vitro experiments, human lung cells were directly exposed to freshly produced aerosols in a closed exposure system. Immunology eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Cannabidiol exposure caused significantly higher induction of inflammatory and lung damage markers than nicotine exposure. Specifically, mice exposed to cannabidiol aerosols showed higher levels of CD4+ and CD8+ T cells and higher infiltration of neutrophils in the lung compared to nicotine-exposed mice.
A significant reduction in the number of anti-inflammatory macrophages was observed in the lungs of cannabidiol-exposed mice. This could potentially cause lung immune dysfunction and lung damage and increase lung infection risk. Common flavoring chemicals used in cannabidiol vaping products could further augment cannabidiol-induced lung macrophage dysfunction.
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