Study finds evidence of resistance to COVID-19 drugs umnmedschool ScienceAdvances
nirmatrelvir, the active component of Paxlovid, the study found that a different set of mutations currently in circulation can transfer resistance to ensitrelvir , a protease inhibitor now approved in Japan. This new research shows that simple single amino acid changes in SARS-CoV-2 main protease could severely undermine efficacy of these antiviral drugs.
Further research is likely to develop additional next-generation protease inhibitors with different resistance profiles, as well as drugs that target different viral processes such as replication or cell entry. A multi-approach—like existing therapies for HIV and Hepatitis C virus—could further help to protect against resistance and cure SARS-CoV-2-infected individuals.
"Despite Paxlovid's proven success in blunting COVID-19 symptoms, the long-term consequences of its widespread use in speeding up resistance are unknown," said S. Arad Moghadasi, co-author of the study and a University of Minnesota Medical School graduate student."Drugs with the highest barriers to resistance are likely to prove more effective and have longer-term durability.
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