Fighting cancer is exhausting for T cells. Hostile tumor microenvironments can drain their mitochondrial activity, leading to a condition known as T cell exhaustion. This phenomenon also hinders adoptive cell therapies, in which healthy, tumor-targeting T cells are infused into patients with cancer.
Study finds 'supercharging' T cells with mitochondria enhances their antitumor activity retrieved 13 September 2024 from https://medicalxpress.com/news/2024-09-supercharging-cells-mitochondria-antitumor.html
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