A new study in mice hints at the promise of an eventual alternative treatment option for the 'wet' version of age-related macular degeneration (AMD).
Ohio State UniversityJul 2 2024 A new study in mice hints at the promise of an eventual alternative treatment option for the "wet" version of age-related macular degeneration .
Anti-VEGF treatment has shortcomings – after two years, about half of people stop responding. And patients can develop scarring under the retina. There is a need for better understanding of the mechanisms behind this problem, which, to me, means newer targets need to be tested." Dry age-related macular degeneration constitutes about 80% of all AMD cases, and occurs when the macula, a part of the retina, gets thinner, leading to buildup of proteins and cell death, which blur a person's central vision.
Previous cancer research has linked high activity of telomerase to rapid production and migration of cells lining blood vessels that enables tumor growth, and has also shown the enzyme can stimulate production of VEGF. Based on those findings, Kerur and colleagues sought in this study to see if telomerase could have a similar damaging effect in the eye.
The team then tested the effects of an experimental compound that inhibits telomerase activity. They confirmed that the drug lowered telomerase activity in healthy mice, and found that injecting it into the eyes of mice with symptoms mimicking wet AMD significantly reduced the abnormal blood vessel invasion.
Age-Related Macular Degeneration Blood Blood Vessel Blood Vessels Cell Drugs Enzyme Eye Genes Growth Factor Ophthalmology Protein Research Telomerase Vascular VEGF
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