People eat either because they are hungry or for pleasure, even in the absence of hunger. While hunger-driven eating is fundamental for survival, pleasure-driven feeding may accelerate the onset of obesity and associated metabolic disorders.
Baylor College of Medicine Aug 9 2024 A study published in Nature Metabolism reveals neural circuits in the mouse brain that promote hunger-driven feeding and suppress pleasure-driven eating. The findings open new possibilities for developing strategies to combat obesity.
Previous studies have highlighted the role of neurons identified by the GABAergic proenkephalin marker, an endogenous opioid hormone, on feeding and body weight balance. However, their contribution to regulating hunger- and pleasure-driven feeding had not been elucidated. The researchers investigated the mechanism mediating these opposite effects. They discovered that DBB-Penk neurons project into two different brain areas, one regulates hunger-driven feeding and the other controls pleasure-driven eating.
Children Hospital Hypothalamus Medicine Metabolic Disorders Metabolism Neurons Nutrition Obesity Pediatrics Research
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