For the 314,000 people diagnosed with ovarian cancer each year, hope often comes in the form of platinum-based drugs such as cisplatin.
Cisplatin causes the death of quick-dividing tumour cells, so it is a potent first-line defence in the treatment of the often fatal disease.
SOD1 off! The study extends previous work on ovarian cancer cells that showed cisplatin-resistant tumour cells had high levels of SOD1 as a result of damage induced by cisplatin treatment side effects. The results suggested that reducing SOD1 levels can stop cells from becoming resistant to the chemotherapeutic drug.
The results showed that when the siRNA was successfully transported and released into tumour tissue six times over 14 days in female mice, the tumour showed reduced growth and decreased resistance to cisplatin. Targeting delivery To deliver the siRNA to the tumour tissue, the team injected female mice with nanoparticles made out of graphene oxide. The siRNA was contained within the nanoparticles, which have been successful as siRNA carriers in other studies.
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